Once you "generally" figure out how you want to edit (lots of good advice just above) you let PPro help you... per instructions below
Please NOTE that the PPro CS6 screen may look a bit different (I use CS5)
For CS5 and later, the easy way to insure that your video and your project match
See 2nd post for picture of NEW ITEM process http://forums.adobe.com/thread/872666
-and a FAQ on sequence setting http://forums.adobe.com/message/3804341